Etiology:
Thrombotic thrombocytopenic purpura (TTP)
Hemolytic uremic syndrome (HUS)
Disseminated intravascular coagulation (DIC)
Malignant hypertension
- Pathogenesis:
Small vessel platelet-rich thrombi → Shearing of RBCs → Schistocytes
RBC fragmentation → Hemolysis → Anemia
- Clinical Features:
Hemolytic anemia
Thrombocytopenia
Organ dysfunction (kidney, CNS, heart)
Schistocytes on peripheral smear
- Treatment:
Plasma exchange (TTP)
Supportive care (HUS, DIC)
Manage underlying condition